Praesto Q45

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Praesto Q是一种琼脂糖基质的强阴离子交换填料,用来纯化生物分子,包括蛋白质、肽和寡核苷酸。有三种粒径的填料可供选择 – 45μm,65μm90μm –  根据不同粒径来获得高分辨率、适度分辨率或者捕获阶段。

同时Purolite 还提供‘Jetting’工艺生产的均粒强阴离子交换填料,Jetted Q35

如您有更多相关的疑问,可点击FAQs获得更多相关信息。

PRINCIPAL APPLICATIONS

  • Protein purification (20-500 kDa)
  • MAb Purification

REGULATORY APPROVALS

  • Manufactured under cGMP conditions

ADVANTAGES

  • High dynamic binding capacity
  • Enhanced pressure/flow performance
  • High resolution/selectivity
  • Chemical and physical stability
  • Secure, validated supply and regulatory support

TYPICAL PACKAGING

  • Bulk Resin
  • Production-Scale OPUS® Columns
  • OPUS® Robocolumns®
  • OPUS® MiniChrom Columns
  • HT Columns
TYPICAL PHYSICAL & CHEMICAL CHARACTERISTICS:
Polymer Structure Highly cross linked agarose
Appearance Spherical beads
Functional Group Quaternary amine
Chemical stability All commonly used aqueous buffers. 1M NaOH, 8M urea, 6M guanidine hydrochloride, 30% isopropanol and 70% ethanol
Avoid Oxidising agents, anionic detergents
Ionic capacity – resin 0.14 – 0.18 mmol/ml
Ionic capacity – medium 0.14 – 0.18 mmol Cl⁻/ml
Particle Size – µm 45µm
Dynamic Binding Capacity (min.) – 6 minutes residence time 70 BSA/ml
Pressure/flow (min.) – at 3 bar in a 2.6 x 20 cm column (pressure-packed at 4 bar) 200 cm/h
pH stability, CIP (short term) 2 – 14
pH stability, working range 3 – 13
Recommended Storage 4 – 30 °C
Recommended Storage 20% ethanol